Potential for Developing Plant-Derived Candidate Vaccines and Biologics against Emerging Coronavirus Infections
The rising human coronavirus infections within the 21st century stay a significant public well being disaster inflicting worldwide impression and difficult the worldwide well being care system. The virus is circulating in a number of zoonotic hosts and constantly evolving, inflicting occasional outbreaks as a consequence of spill-over occasions occurring between animals and people.
Therefore, the event of efficient vaccines or therapeutic interventions is the present international precedence with a view to cut back illness severity, frequent outbreaks, and to stop future infections. Vaccine improvement for newly rising pathogens takes a very long time, which hinders fast immunization packages.
The idea of plant-based prescription drugs will be readily utilized to satisfy the recombinant protein demand by way of transient expression. Crops are advanced as an expression platform, they usually deliver a mixture of distinctive pursuits by way of fast scalability, flexibility, and financial system for industrial-scale manufacturing of efficient vaccines, diagnostic reagents, and different biopharmaceuticals.
Crops provide protected biologics to meet emergency calls for, particularly throughout pandemic conditions or outbreaks brought on by rising strains. This overview highlights the options of a plant expression platform for producing recombinant biopharmaceuticals to fight coronavirus infections with emphasis on COVID-19 vaccine and biologics improvement.
Biologic Therapies and Autoimmune Phenomena
The usage of biologic drugs has represented a fantastic development within the therapy of autoimmune rheumatic illnesses. Regardless of their glorious efficacy, over the past years, a rising variety of stories of autoimmune phenomena and paradoxical irritation has emerged.
These phenomena could vary from the invention of an remoted autoantibody to full-blown autoimmune illnesses, organ-specific and systemic. This overview has been carried out with a view to underline the multitude of the potential adversarial manifestations from the usage of biologic drugs.
Thus, early recognition of particular forms of autoimmune phenomena is an crucial for the physicians permitting them to have an correct analysis and therapy.
A peptide-based anti-Adalimumab antibody assay to watch immune response to biologics therapy in juvenile idiopathic arthritis and childhood power non-infectious uveitis
Immune response to biologics therapy, whereas extensively reported, but fails to correlate with medical outcomes and assay to assay comparability is commonly not potential. Therefore, we developed a brand new peptide based-detection assay to stratify pediatric sufferers with juvenile idiopathic arthritis (JIA) or power non-infectious uveitis (CNU) and monitor anti-drug antibodies (ADAbs) shaped as a part of an immune response to therapy with the absolutely human monoclonal therapeutic antibody Adalimumab.
Adalimumab derived artificial peptides have been optimized for optimum immunogenicity and have been examined by SP-ELISA on a improvement cohort of 18 JIA and CNU handled sufferers. The 2 greatest performing peptides capable of differentiate affected person teams have been chosen for analysis with a bigger scale ELISA testing on a complete of 29 sera from pediatric sufferers with JIA or CNU.
The outcomes of this peptide-based assay have been in comparison with an in-house developed SPR biosensor ADAbs assay and a commercially out there bridging ELISA. The primary peptide, termed HC3, was capable of positively detect ADAbs in 7 out of the 29 sera, whereas the second peptide, referred to as LC3, was capable of detect ADAbs in 11 out of 29 sera within the analysis group.
Following statistical knowledge analysis, it has been discovered that the detection of ADAbs utilizing the peptide-based ELISA assay positively correlates with illness development and remission.
Two artificial peptides derived from Adalimumab could present a helpful instrument to clinicians for monitoring affected person response to such therapy and taking knowledgeable choices for therapy options.
Investigation of Elements Related to Immunogenicity Labeling Updates and Traits of Biologics License Functions
Immunogenicity, the potential to elicit an anti-drug immune response, is a essential concern in creating organic merchandise, however its penalties are tough to foretell with animal research. The goals of the current examine are to analyze the evolution of immunogenicity data in labeling and to establish attributes related to immunogenicity labeling updates.
Biologics License Functions (BLAs) authorised by the Heart for Drug Analysis and Analysis, United States Meals and Drug Administration between 2008 and 2017 have been studied. A majority of BLAs described the incidence/prevalence of anti-drug antibodies (ADAs) (94.9%) and neutralizing antibodies (NAbs) (68.4%) of their authentic labeling paperwork.
Nevertheless, lower than one-third of the BLAs talked about the impression of ADAs/NAbs within the authentic (20.3%) and most up-to-date (29.1%) labeling paperwork. BLAs with a precedence overview standing (57.4% versus 33.3%), orphan designation (61.5% versus 34.2%), or a point out of ADA impression within the newest label (69.6% versus 38.9%) had larger percentages of purposes with postmarketing necessities (PMRs) straight associated to immunogenicity issues compared with purposes with out these traits.
Among the many BLAs with up to date immunogenicity data, the imply time to the primary replace was 1077 days, whereas that for BLAs with accelerated approval was shorter (709.1 ± 492.2 days versus 1173.8 ± 661.Eight days).
The outcomes recommend that there’s a substantial quantity of essential data missing within the authentic labeling paperwork and an overdependence on PMRs for extra proof. Further efforts ought to be made to analyze the impression of ADAs to supply well timed data for improved affected person care.
Part I Research to Assess Security of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Sufferers With Persistent Plaque-Sort Psoriasis
Ablative fractional laser therapy facilitates epidermal drug supply, which may be an fascinating choice to extend the topical efficacy of organic medication in a wide range of dermatological illnesses. This work goals at investigating security and tolerability of this new therapy method in sufferers with plaque-type psoriasis. Eight sufferers with plaque-type psoriasis have been enrolled on this examine.
All sufferers obtained (i) ablative fractional laser microporation (AFL) of a psoriatic lesion with an Er:YAG laser + etanercept (ETA; Enbrel® answer for injection) (AFL-ETA), (ii) ETA alone on one other lesion, and, if possible, (iii) AFL alone on an extra lesion. Total, all therapy arms confirmed a positive security profile. AFL-ETA improved the lesion-specific TPSS rating by 1.75 vs. baseline, whereas ETA or AFL alone confirmed a TPSS rating enchancment of 0.75 factors, a distinction that was not statistically vital and may be attributable to variations in baseline scores.
Guanidine Thiocyanate (GTC) for molecular biology, 99% |
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| 80272 | Sisco Laboratories | 100 Gms | EUR 5.47 |
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Description: Part A |
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Tris Hydrochloride (Tris HCl) for molecular biology, 99% |
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| 89781 | Sisco Laboratories | 100 Gms | EUR 9.37 |
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Description: Part A |
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Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE164 | GeneOn | 100 g | EUR 86.4 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE165 | GeneOn | 500 g | EUR 192 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 307.2 |
Acridine Orange Hydrochloride Hydrate for molecular biology, 99% |
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| 82407 | Sisco Laboratories | 1 Gms | EUR 10.58 |
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Description: Part B |
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Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 99.6 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 144 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 223.2 |
1M Tris Hydrochloride Buffer (1M Tris HCl) pH-8.0 for molecular biology |
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| 55904 | Sisco Laboratories | 100 ml | EUR 12.3 |
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Description: Part B |
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1M Tris Hydrochloride Buffer (1M Tris HCl) pH-7.2 for molecular biology |
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| 79091 | Sisco Laboratories | 100 ml | EUR 8.33 |
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Description: Part B |
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Guanidine Hydrochloride |
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| 09860-25 | NACALAI TESQUE | 500G | EUR 224 |
Guanidine Hydrochloride |
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| 17318-24 | NACALAI TESQUE | 10KG | EUR 742 |
Guanidine Hydrochloride |
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| 17318-82 | NACALAI TESQUE | 25G | EUR 14 |
Guanidine Hydrochloride |
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| 17318-95 | NACALAI TESQUE | 500G | EUR 68.6 |
Guanidine Hydrochloride |
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| 17319-14 | NACALAI TESQUE | 100G | EUR 32.2 |
Guanidine Hydrochloride |
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| 17319-85 | NACALAI TESQUE | 500G | EUR 84 |
Guanidine Hydrochloride |
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| 17353-25 | NACALAI TESQUE | 500G | EUR 147 |
Guanidine Hydrochloride |
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| 18-206 | Genesee Scientific | 500g/Unit | EUR 191.53 |
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Description: Molecular/Proteomic Grade |
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Guanidine Hydrochloride |
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| 40700060-1 | Glycomatrix | 100 g | EUR 36.33 |
Guanidine Hydrochloride |
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| 40700060-2 | Glycomatrix | 500 g | EUR 89.21 |
Guanidine Hydrochloride |
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| 40700060-3 | Glycomatrix | 1 kg | EUR 153.37 |
Guanidine Hydrochloride |
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| A2719-100G | Biomatik Corporation | 100G | EUR 30.8 |
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Description: Biotechnology |
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Guanidine Hydrochloride |
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| A2719-500G | Biomatik Corporation | 500G | EUR 97.9 |
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Description: Biotechnology |
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Guanidine Hydrochloride |
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| G821245 | Toronto Research Chemicals | 10g | EUR 63 |
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Description: 50-01-1 |
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Guanidine (hydrochloride) |
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| HY-B0178A | MedChemExpress | 50g | EUR 159.6 |
Guanidine hydrochloride |
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| GB0242 | Bio Basic | 100g | EUR 80.88 |
Guanidine hydrochloride |
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| T0415-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Guanidine hydrochloride |
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Guanidine hydrochloride |
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| T0415-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Guanidine hydrochloride |
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Guanidine hydrochloride |
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| T0415-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Guanidine hydrochloride |
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Guanidine hydrochloride |
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| T0415-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Guanidine hydrochloride |
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Guanidine hydrochloride |
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| T0415-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Guanidine hydrochloride |
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Guanidine Hydrochloride |
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| MBS6036459-100g | MyBiosource | 100(g | EUR 170 |
Guanidine Hydrochloride |
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| MBS6036459-10kg | MyBiosource | 10kg | EUR 2865 |
Guanidine Hydrochloride |
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| MBS6036459-1kg | MyBiosource | 1kg | EUR 395 |
Guanidine Hydrochloride |
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| MBS6036459-25kg | MyBiosource | 2.5kg | EUR 830 |
Guanidine Hydrochloride |
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| MBS6036459-500g | MyBiosource | 500g | EUR 275 |
Guanidine hydrochloride |
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| MBS3604673-100mg | MyBiosource | 100mg | EUR 250 |
Guanidine hydrochloride |
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| MBS3604673-200mg | MyBiosource | 200mg | EUR 285 |
Guanidine hydrochloride |
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| MBS3604673-25mg | MyBiosource | 25mg | EUR 200 |
Guanidine hydrochloride |
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| MBS3604673-500mg | MyBiosource | 500mg | EUR 325 |
Guanidine hydrochloride |
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| MBS3604673-50mg | MyBiosource | 50mg | EUR 215 |
Guanidine thiocyanate?For Molecular Biol |
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| MB015-1KG | EWC Diagnostics | 1 unit | EUR 118.81 |
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Description: Guanidine thiocyanate?For Molecular Biol |
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Guanidine thiocyanate?For Molecular Biol |
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| MB015-500G | EWC Diagnostics | 1 unit | EUR 79.2 |
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Description: Guanidine thiocyanate?For Molecular Biol |
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Guanidine hydrochloride, 99% |
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| GE1914 | Glentham Life Sciences | 25g | EUR 72.46 |
Guanidine hydrochloride, 99% |
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| GE1914-1 | Glentham Life Sciences | 1 | EUR 79.1 |
Guanidine hydrochloride, 99% |
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| GE1914-100 | Glentham Life Sciences | 100 | EUR 15.9 |
Guanidine hydrochloride, 99% |
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| GE1914-100G | Glentham Life Sciences | 100 g | EUR 55.2 |
Guanidine hydrochloride, 99% |
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| GE1914-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Guanidine hydrochloride, 99% |
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| GE1914-25 | Glentham Life Sciences | 25 | EUR 13 |
Guanidine hydrochloride, 99% |
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| GE1914-250 | Glentham Life Sciences | 250 | EUR 23.8 |
Guanidine hydrochloride, 99% |
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| GE1914-250G | Glentham Life Sciences | 250 g | EUR 64.8 |
Guanidine hydrochloride, 99% |
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| GE1914-25G | Glentham Life Sciences | 25 g | EUR 50.4 |
Guanidine hydrochloride, 99% |
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| GE1914-500 | Glentham Life Sciences | 500 | EUR 43.5 |
Guanidine hydrochloride, 99% |
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| GE1914-500G | Glentham Life Sciences | 500 g | EUR 88.8 |
Guanidine hydrochloride powder |
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| G05320 | Pfaltz & Bauer | 100G | EUR 126.5 |
Guanidine-15N3 Hydrochloride |
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| G821249 | Toronto Research Chemicals | 25mg | EUR 1200 |
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Description: 121616-39-5 |
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Guanidine-d5 (hydrochloride) |
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| HY-B0178AS1 | MedChemExpress | Get quote | Ask for price |
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Description: Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3]. |
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Guanidine hydrochloride solution, 8M |
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| GE1001 | Glentham Life Sciences | 100ml | EUR 386.21 |
Guanidine hydrochloride solution, 6M |
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| GE4739 | Glentham Life Sciences | 100ml | EUR 651.82 |
Guanidine hydrochloride solution, 8M |
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| GE1001-100 | Glentham Life Sciences | 100 | EUR 120.5 |
Guanidine hydrochloride solution, 8M |
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| GE1001-500 | Glentham Life Sciences | 500 | EUR 421.8 |
Guanidine hydrochloride solution, 6M |
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| GE4739-1 | Glentham Life Sciences | 1 | EUR 711.9 |
Guanidine hydrochloride solution, 6M |
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| GE4739-100 | Glentham Life Sciences | 100 | EUR 118.7 |
Guanidine hydrochloride solution, 6M |
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| GE4739-500 | Glentham Life Sciences | 500 | EUR 408.1 |
Guanidine Hydrochloride 7M Solution |
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| MBS6069932-100mL | MyBiosource | 100mL | EUR 255 |
Guanidine Hydrochloride 7M Solution |
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| MBS6069932-1L | MyBiosource | 1L | EUR 650 |
Guanidine Hydrochloride 7M Solution |
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| MBS6069932-2L | MyBiosource | 2L | EUR 1130 |
Guanidine Hydrochloride 7M Solution |
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| MBS6069932-2x2L | MyBiosource | 2x2L | EUR 1875 |
Guanidine Hydrochloride 7M Solution |
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| MBS6069932-500mL | MyBiosource | 500mL | EUR 435 |
Guanidine Hydrochloride 6M Solution |
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| MBS635447-100mL | MyBiosource | 100mL | EUR 250 |
Guanidine Hydrochloride 6M Solution |
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| MBS635447-1L | MyBiosource | 1L | EUR 610 |
Guanidine Hydrochloride 6M Solution |
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| MBS635447-2L | MyBiosource | 2L | EUR 1090 |
Guanidine Hydrochloride 6M Solution |
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| MBS635447-2x2L | MyBiosource | 2x2L | EUR 1795 |
Guanidine Hydrochloride 6M Solution |
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| MBS635447-500mL | MyBiosource | 500mL | EUR 395 |
Guanidine Hydrochloride 8M Solution |
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| MBS635271-100mL | MyBiosource | 100mL | EUR 260 |
Guanidine Hydrochloride 8M Solution |
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| MBS635271-1L | MyBiosource | 1L | EUR 680 |
Guanidine Hydrochloride 8M Solution |
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| MBS635271-2L | MyBiosource | 2L | EUR 1155 |
Guanidine Hydrochloride 8M Solution |
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| MBS635271-2x2L | MyBiosource | 2x2L | EUR 1910 |
Guanidine Hydrochloride 8M Solution |
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| MBS635271-500mL | MyBiosource | 500mL | EUR 485 |
Guanidine-13C,15N3 (hydrochloride) |
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| HY-B0178AS | MedChemExpress | 1mg | Ask for price |
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Description: Guanidine-13C,15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2]. |
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Guanidine hydrochloride, Hi-LR™ |
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| GRM1504-100G | EWC Diagnostics | 1 unit | EUR 46.61 |
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Description: Guanidine hydrochloride, Hi-LR™ |
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Guanidine hydrochloride, Hi-LR™ |
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| GRM1504-25G | EWC Diagnostics | 1 unit | EUR 13.32 |
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Description: Guanidine hydrochloride, Hi-LR™ |
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Guanidine Hydrochloride (GHC) pure, 99% |
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| 54542 | Sisco Laboratories | 100 Gms | EUR 3.01 |
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Description: Part A |
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Guanidine hydrochloride (6 M) solution |
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| B1013-1L | Biovision | each | EUR 301.2 |
Guanidine hydrochloride (6 M) solution |
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| B1013-4L | Biovision | each | EUR 705.6 |
1-(2,4-difluorophenyl)guanidine hydrochloride |
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| T50030-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: 1-(2,4-difluorophenyl)guanidine hydrochloride |
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1-(2,4-difluorophenyl)guanidine hydrochloride |
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| T50030-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: 1-(2,4-difluorophenyl)guanidine hydrochloride |
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1-(2,4-difluorophenyl)guanidine hydrochloride |
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| T50030-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: 1-(2,4-difluorophenyl)guanidine hydrochloride |
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1-(2,4-difluorophenyl)guanidine hydrochloride |
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| T50030-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: 1-(2,4-difluorophenyl)guanidine hydrochloride |
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1-(2,4-difluorophenyl)guanidine hydrochloride |
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| T50030-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: 1-(2,4-difluorophenyl)guanidine hydrochloride |
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1-(2,4-difluorophenyl)guanidine hydrochloride |
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| MBS5785869-10mg | MyBiosource | 10mg | EUR 180 |
1-(2,4-difluorophenyl)guanidine hydrochloride |
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| MBS5785869-25mg | MyBiosource | 25mg | EUR 235 |
1-(2,4-difluorophenyl)guanidine hydrochloride |
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| MBS5785869-50mg | MyBiosource | 50(mg | EUR 300 |
1-(2,4-difluorophenyl)guanidine hydrochloride |
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| MBS5785869-5mg | MyBiosource | 5(mg | EUR 155 |
N-(3,4-Dimethoxyphenyl)guanidine Hydrochloride |
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| D470625 | Toronto Research Chemicals | 10g | EUR 800 |
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Description: 855890-38-9 |
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N-Cyano-N'-(6-guanidinohexyl) Guanidine Hydrochloride |
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| C655610 | Toronto Research Chemicals | 250mg | EUR 400 |
N-(4-Methyl-2-thiazolyl)-guanidine hydrochloride |
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| M331435 | Toronto Research Chemicals | 100mg | EUR 58 |
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Description: 100599-91-5 |
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N-(6-Aminohexyl)-N'-(6-guanidinohexyl) Guanidine Hydrochloride |
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| A544590 | Toronto Research Chemicals | 50mg | EUR 6000 |
Casein, for Molecular Biology |
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| MB279-100G | EWC Diagnostics | 1 unit | EUR 110.77 |
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Description: Casein, for Molecular Biology |
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Casein, for Molecular Biology |
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| MB279-500G | EWC Diagnostics | 1 unit | EUR 387.65 |
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Description: Casein, for Molecular Biology |
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Sucrose for molecular biology |
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| 27580 | Sisco Laboratories | 500 Gms | EUR 4.11 |
|
Description: Part A |
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1-(4-Chloromethyl-2-thiazoyl)guanidine Hydrochloride Salt |
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| C369545 | Toronto Research Chemicals | 1g | EUR 146 |
1-(4-Chloromethyl-2-thiazoyl)guanidine Hydrochloride Salt |
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| MBS6102657-5g | MyBiosource | 5(g | EUR 515 |
1-(4-Chloromethyl-2-thiazoyl)guanidine Hydrochloride Salt |
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| MBS6102657-5x5g | MyBiosource | 5x5g | EUR 2175 |
Urea for molecular biology, 99.5% |
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| 21113 | Sisco Laboratories | 500 Gms | EUR 6.5 |
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Description: Part A |
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Xylene for molecular biology, 99.5% |
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| 45122 | Sisco Laboratories | 250 ml | EUR 2.81 |
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Description: Part A |
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Acetone for molecular biology, 99.8% |
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| 27498 | Sisco Laboratories | 500 ml | EUR 3.76 |
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Description: Part A |
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Glycine for molecular biology, 99.5% |
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| 64072 | Sisco Laboratories | 100 Gms | EUR 1.64 |
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Description: Part A |
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Carbinol for molecular biology, 99.5% |
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| 34883 | Sisco Laboratories | 500 ml | EUR 6.23 |
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Description: Part A |
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Methanol for molecular biology, 99.5% |
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| 96446 | Sisco Laboratories | 500 ml | EUR 6.23 |
|
Description: Part A |
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Formamide for molecular biology, 99.5% |
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| 30349 | Sisco Laboratories | 500 ml | EUR 5.82 |
|
Description: Part A |
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1-(4-Chloromethyl-2-thiazoyl)guanidine-13C3 Hydrochloride Salt |
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| MBS6089660-1mg | MyBiosource | 1(mg | EUR 605 |
1-(4-Chloromethyl-2-thiazoyl)guanidine-13C3 Hydrochloride Salt |
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| MBS6089660-5x1mg | MyBiosource | 5x1mg | EUR 2565 |
Imidazole for molecular biology, 99.5% |
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| 61510 | Sisco Laboratories | 25 Gms | EUR 5.47 |
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Description: Part A |
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Chloroform for molecular biology, 99.8% |
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| 96764 | Sisco Laboratories | 100 ml | EUR 3.08 |
|
Description: Part A |
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Urea, suitable for molecular biology |
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| GE1210 | Glentham Life Sciences | 500g | EUR 53.1 |
Urea, suitable for molecular biology |
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| GE1210-1 | Glentham Life Sciences | 1 | EUR 58 |
Urea, suitable for molecular biology |
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| GE1210-1KG | Glentham Life Sciences | 1 kg | EUR 106.8 |
Urea, suitable for molecular biology |
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| GE1210-500 | Glentham Life Sciences | 500 | EUR 33.1 |
Urea, suitable for molecular biology |
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| GE1210-500G | Glentham Life Sciences | 500 g | EUR 76.8 |
Triethylamine for molecular biology, 99.5% |
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| 55221 | Sisco Laboratories | 500 ml | EUR 4.11 |
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Description: Part A |
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Ficoll 400® for molecular biology |
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| 45460 | Sisco Laboratories | 5 Gms | EUR 15.6 |
|
Description: Part B |
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Agarose UltraPhor for molecular biology |
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| 27813 | Sisco Laboratories | 10 Gms | EUR 46.5 |
|
Description: Part B |
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Boric Acid for molecular biology, 99.5% |
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| 22311 | Sisco Laboratories | 250 Gms | EUR 4.04 |
|
Description: Part A |
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2-Mercaptoethanol ?For Molecular Biology |
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| MB041-100ML | EWC Diagnostics | 1 unit | EUR 9.02 |
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Description: 2-Mercaptoethanol ?For Molecular Biology |
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2-Mercaptoethanol ?For Molecular Biology |
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| MB041-500ML | EWC Diagnostics | 1 unit | EUR 26.47 |
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Description: 2-Mercaptoethanol ?For Molecular Biology |
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ACES Buffer for molecular biology, 99.5% |
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| 27907 | Sisco Laboratories | 5 Gms | EUR 5.4 |
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Description: Part B |
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Triton X-100 for molecular biology |
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| 64518 | Sisco Laboratories | 100 ml | EUR 6.02 |
|
Description: Part A |
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MOPS Buffer for molecular biology, 99% |
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| 66043 | Sisco Laboratories | 25 Gms | EUR 10.28 |
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Description: Part B |
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Topical administration of ETA to psoriatic plaques by way of AFL-generated micropores was usually well-tolerated. No particular precautions appear mandatory in future research. Scientific profit will want evaluation in sufficiently powered follow-up research.
